Empty offices in Stratford are set to be replaced with a 151-room Travelodge hotel.
Gredley House in Broadway will be transformed into Travelodge's 85th London hotel after planning permission was given the go-ahead.
The Stratford development will be the hotel company's closest hotel to Stratford station, connecting passengers from National Rail, Underground and DLR services.
Construction will get underway in May, led by Barnes Construction, with plans for the hotel to be open to the public at the end of 2025.
The construction group are the current contractor for London Chiswick's Travelodge, and previously built the London Wimbledon Central Travelodge.
The Stratford Travelodge will be accompanied by a new 85 Bar Cafe which is expected to bring a modern space for guests to eat and drink.
Tony O'Brien, Travelodge's UK development director, said: “Travelodge is delighted to continue the expansion of our network of hotels throughout London and this new hotel in the thriving hub of Stratford will be a fantastic addition to our portfolio.
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"This type of development is a win-win solution for all parties, as it converts redundant space back into economic use, which is a highly sustainable way of developing, delivers significant inward investment and creates new jobs."
Travelodge has agreed a 25-year lease with the building's owner, Unex Group.
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